Pre-Clinical Medicine


Topics covered: Adverse drug reactions, Alzheimer’s disease, Anti-emetrics, Anti-Parkinsonians and neuroleptics, Antibiotics and antifungals, Anticonvulsants, Antidepressants, Antivirals, Anxiolytics and hypnotics, Bioavailability, Cholinoceptor antagonists, Cholinomimetics, Diuretics, Drug-receptor interactions, Drugs affecting the heart, Drugs and vasculature, Drugs of abuse, Gastric and uodenal ulcers, Haemostasis and thrombosis, IBD, Introduction to the ANS, Lipids, Mechanisms of drug action, Neuromuscular blocking drugs, NSAIDs, Opiates and opioids, Pharmacokinetics, Principles of general anaesthesia, Principles of local anaesthesia, SNS agonists, SNS antagonists


Topics included: Biochemistry, Endocrinology, Neuroscience, Cardiovascular system, Respiratory system, Urinary system, Alimentary system, Anatomy of the thorax, Anatomy of the Abdomen and Pelvis, Epidemiology


Topics covered: Bacterial classification (with mnemonics), Portals of entry, Bacterial vaccination, Bacterial disease, Types of antibiotics and resistance, Classification of viruses, Viral modes of transport, Viral vaccinations, Patterns of viral infection, Emergence on new viruses, Fungal classification, Classes of fungicides, Hospital acquired infection


Topics covered: Protein structure, bonding, folding and post-translational modification, Energetics and enzymes, Glycogenolysis, Lysozyme, Alcoholic fermentation, Glycolysis, Pyruvate dehydrogenase complex, The Krebs Cycle, Oxidative Phosphorylation, Malate-Aspartate Shuttle, Glycerol Phosphate Shuttle, Amino acid metabolism, Metabolic poisons, Lipid metabolism, Beta-oxidation cycle, Ketone body formation, Fatty acid biosynthesis, Cholesterol synthesis and metabolism, Membrane trafficking, Integration of metabolism e.g. with endocrinology, Gluconeogenesis


Topics covered: Glycolysis, Pyruvate oxidation, The Krebs Cycle, Oxidative Phosphorylation, Cholesterol synthesis, Beta-oxidation, Gluconeogenesis, Carbohydrate metabolism, Protein metabolism, Fatty Acid Biosynthesis


Topics covered: Congenital defects, Genetic disorders (e.g. trisomies, dosage compensation, aneuploidy, genomic disorders and more), Transmission of genetic disease, Types of inheritance patterns, Genomic imprinting, DNA methylation, Mitochondrial genome and inheritance + disorders, Cancer in families and individuals, Pharmacogenetics, Two-hit hypothesis, Prenatal testing, Genetic counselling, Complex genetic diseases, Future of genomic medicine e.g. personalised/ precision medicine


Topics covered: Introduction to immunology (role of the immune system, types of immunity etc.), Immune cells and organs, T and B cell receptors, Antigen presenting cells, Innate immunity, Complement system, Major histocompatibility complex (MHC), Antibodies, Immunoglobin classes and sub-classes, B lymphocytes + Clonal selection, Immunological memory, T lymphocytes and antigen recognition, The thymus, Effector T lymphocytes, Regulation of lymphocyte responses, Central and peripheral tolerance


Topics covered: Introduction to Endocrinology (hormone classifications, synthesis, transport), Hormone signalling, The anterior pituitary gland + hormones, The posterior pituitary gland + hormones, Insulin secretion and metabolism, Diabetes mellitus, The thyroid + Iodothyronines, Thyroid disorders, The adrenals + hormones, Adrenal disorders, The gonads, Menstrual cycle + Amenorrhoea, Gonadal disorders, Endocrine control of calcium metabolism